Clinical trials information

The NF Tumor Metrics Service is managed in parallel with the Tumor Imaging Metrics Core (TIMC), which provides standardized measurements of radiological scans for clinical trials (

The TIMC's primary services include:

  • Consultation for protocol design
  • Image capture of radiological scans from local or remote sites
  • Quantitative and qualitative measurement of tumors according to trial protocol

Since its inception in 2005, TIMC has analyzed more than 20,000 scans for 350 clinical trials, including therapeutic clinical trials for NF patients. Independent site and central reads can be provided.

In an anonymous survey, clinical trial staff reported that TIMC's services are fast, accurate, and greatly improve the reliability of lesion response measurement. An in-house study of inter-rater reliability among image analysts resulted in a reliability coefficient of 0.94.